This study aimed to model the structural equation of academic research commercialization with an approach focused on the development of knowledge-based employment in the health system. This research is descriptive-survey in nature and employed structural equation modeling methods. The statistical population included managers of research centers, faculty members, deputies, and senior managers of medical universities and designated universities under the Ministry of Science. A simple random sampling method was used to select the statistical sample. In this study, a questionnaire was prepared, and responses were collected and analyzed from 400 managers of research centers, faculty members, deputies, and senior managers of medical universities and designated universities of the Ministry of Science. The purpose of data analysis was to examine the proposed research model in the form of a path analysis model and test the predicted relationships and connections within the model. The structural equation modeling method was used for causal analysis of the proposed model. Data processing was conducted using SPSS software. For qualitative data analysis, the grounded theory approach was used, and for quantitative data analysis, partial least squares (PLS) were utilized using Smart PLS software. The results indicated that the commercialization model of academic research with a knowledge-based employment development approach in the health system is valid and desirable. Commercialization of academic research in the medical and health fields plays a crucial role in promoting economic growth and creating knowledge-based employment. By bridging the gap between academia and industry, universities can transform scientific discoveries into innovative products and services that meet critical healthcare needs while simultaneously stimulating economic growth.